This structure is generally monitored with an in-laboratory overnight sleep study, also called a polysomnography (PSG) study. NREM sleep is further sub-divided into three stages–N1, N2 and N3–based on the new American Academy of Sleep Medicine (AASM) rules ( Moser et al., 2009). Sleep is broadly dichotomized into non-rapid eye movement (NREM) sleep and rapid eye movement (REM) sleep. Sleep quantity and quality tend to differ with sex and age as well as among people who suffer from sleep disorders, stress, anxiety, neuropsychiatric disorders, or diabetes ( Redline et al., 2004 Wulff et al., 2010 Ju et al., 2014 Mander et al., 2017 Högl et al., 2018).Ī normal overnight sleep is structured with certain characteristics that reflect a dynamic physiological process. In fact, sleep architecture can reflect human physiology ( Ju et al., 2014 Mander et al., 2017). Sleep is essential for good physical and mental health, yet physical and mental conditions also affect sleep ( Krause et al., 2017 Franks and Wisden, 2021 Paller et al., 2021). All versions of the SSAVE tool can be found on. SSAVE can be used as a Python package, a desktop standalone tool or through a web portal. SSAVE fills an important gap for the rapidly growing field of sleep medicine by providing an easy-to-use tool for sleep-period identification and visualization. SSAVE, introduced here, is open-source software that takes sleep-stage annotations and EEG signals as input, identifies and characterizes periods of NREM and REM sleep, and produces a hypnogram and its time-matched EEG spectrogram. Overnight sleep studies record, in addition to electroencephalography (EEG) and other electro-physiological signals, a sequence of sleep-stage annotations. An overnight sleep study facilitates identification of macro and micro changes in the pattern and duration of sleep stages associated with sleep disorders and other aspects of human mental and physical health. Human sleep architecture is structured with repeated episodes of rapid-eye-movement (REM) and non-rapid-eye-movement (NREM) sleep. 4Department of Neurology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.3Division of Sleep Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.2Department of Engineering Science, Trinity University, San Antonio, TX, United States.1Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, RTP, NC, United States.Amlan Talukder 1 * Yuanyuan Li 1 Deryck Yeung 1,2 David M.
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